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2018心理健康前沿科学论坛
作者: 健康与遗传心理学研究室 ║ 日期: 2018/05/10 

时间:隔周二下午14:00-16:00(有例外) 

地点:心理所北楼一层报告厅(有例外) 

日期

主持人

报告专家

专家单位

报告题目

316

王亮
研究员

Nikolai Axmacher
教授

Ruhr University Bochum, German

Engram patterns: Tracking event-specific representations in the human brain

326

 

Dr. David Belin

the University of Cambridge

Biobehavioural markers of individual vulnerability to addiction: role of the environment

5月22日

李娟
研究员

李春波
教授

上海市精神卫生中心

认知老化的行为干预:从认知训练谈起

         
         
         
         
         
         
         
         
         
         
         
         

时间:522日周二上午9:30-11:00 

地点:心理所北楼一层报告厅 

主持人:李娟研究员 

报告人:李春波教授(上海市精神卫生中心) 

报告题目:认知老化的行为干预:从认知训练谈起 

报告摘要: 

  老龄化及其相关问题已成为人类社会面临的一个重大挑战。我们如何延缓衰老?针对认知老化如何做到一级预防?我们从认知老化可塑性的行为干预作为切入点进行了相关探索研究。首先建立了多领域认知训练干预的方法,并通过系列研究进行疗效验证和可塑性改变的机制探索;近年来进一步探索了有氧锻炼的认知获益等;最后,也将提及重复经颅磁刺激和直流电刺激等物理干预进展,期待着多学科交流碰撞出新的学术火花。 

报告人简介: 

  李春波,医学博士,中国科学院心理研究所博士后(2004-2006)。担任上海交通大学医学院附属精神卫生中心(上海市精神卫生中心)主任医师、教授,副院长,博士生导师(精神病与精神卫生学,神经科学与心理学);上海市重性精神病重点实验室研究组组长;中国科学院脑科学与智能技术卓越创新中心客座研究员。 

  主要学术兼职:中国心理学会老年心理学专业委员会副主任委员;中国心理卫生协会心身医学专业委员会副主任委员;上海市医学会行为医学专科委员会主任委员;上海市医学会临床流行病学与循证医学专委会副主任委员等学术团体职务等。《中华行为医学与脑科学杂志》副总主编,《心理学通讯》副主编,Cochrane Schizophrenia Group编辑, Academic Psychiatry编委。主要进行精神障碍病理学基础与临床研究、循证精神医学研究等,发表学术论文340余篇。 

 

时间:326日周一下午14:00-15:30 

地点:心理所北楼一层报告厅 

报告人:Dr. David Belin ( the University of Cambridge)

报告题目:Biobehavioural markers of individual vulnerability to addiction: role of the environment 

报告摘要: 

Drug addiction results from the interaction between a vulnerable individual, a drug and an environment which interactions and their contribution to the transition from volitional to compulsive drug seeking habits, the hallmark of addiction, are yet to be understood. However, over the last decade the development of novel preclinical models of addiction in rodents, factoring in the notion of inter-individual differences with the operationalisation of the main clinical features of addiction in humans have helped shed a new light on the mechanisms subserving this inter-individual vulnerability to develop compulsive drug seeking habits. The presentations will delve into the psychological constructs of the most recent preclinical models of addiction and will investigate the recent breakthrough in the psychological and neural substrates of the propensity to use drugs and to switch from controlled drug use to maladaptive drug seeking habits.  

Key references: 

  1.    Evidence for addiction-like behavior in the rat, Science 305 (5686), 1014-1017 

  2.    High impulsivity predicts the switch to compulsive cocaine-taking, Science 320 (5881), 1352-1355 

  3.    Pattern of intake and drug craving predict the development of cocaine addiction-like behavior in rats, Biological psychiatry 65 (10), 863-868 

  4.    Evidence for a long-lasting compulsive alcohol seeking phenotype in rats, Neuropsychopharmacology 43 (4), 728 

报告人简介: 

Dr David Belin is a Lecturer in Behavioural Neuroscience at the Department of Psychology of the University of Cambridge and a fellow of Homerton College, Cambridge. 

Dr Belin was born in Blois, France in 1979. He graduated in 2005 in Neuroscience and Neuropharmacology at the University of Bordeaux 2. During his PhD he developed the first preclinical model of cocaine addiction based in the operationalisation of multiple clinical criteria of the pathology as defined in humans. 

Dr Belin then moved to the laboratory of Professor Barry Everitt at the Department of Experimental Psychology of the University of Cambridge in January 2006. With his mentor Dr Belin investigated the corticostriatal mechanisms of cocaine seeking habits and the relationships between impulsivity and compulsive cocaine self-administration, leading to a breakthrough in our understanding of the neurological and psychological mechanisms subserving individual vulnerability to cocaine addiction. 

In 2009 Dr David Belin tenured at the INSERM in France and established his INSERM team in Poitiers (France) which focused on the psychological, neural and cellular mechanisms of individual vulnerability to compulsive disorders and their modulation by the environment. Soon it became apparent that Cambridge is where he wanted to carry out his research and he came back in October 2013, being appointed Lecturer in Neuroscience at the Department of Pharmacology. He moved back to the Department of Psychology in October 2016, where he has now established his research on the psychological and neural mechanisms of compulsive disorders. 

Dr David Belin has authored over 50 publications received the Mémain-Pelletier Award from the French Academy of Science and the Young Investigator Award from the European Behavioural Pharmacology Society. He was one of the first fellows of the FENS/Kavli network of Excellence.  

 

时间:3月16日周五上午10:00-11:30 

地点:心理所 北楼一层报告厅 

主持人:王亮研究员 

报告人: Prof. Nikolai Axmacher (Ruhr University Bochum, German) 

报告题目: Engram patterns: Tracking event-specific representations in the human brain 

报告摘要: 

Can we find the neural representations of specific experiences, or “engrams”, in the human brain? Can these results help to better understand memory dysfunctions? In a series of studies, we used intracranial EEG recordings in epilepsy patients as well as fMRI and simultaneous EEG/fMRI recordings in healthy participants to search for network-level “engram patterns” and to track their fate during memory processing. We identified engram patterns in spatial distributions and time courses of intracranial EEG oscillations as well as in distributed patterns of BOLD responses. Engram patterns were reinstantiated during long-term memory retrieval, and were spontaneously reactivated during awake resting state and sleep. Analyzing content-specific representations may also allow understanding representational abnormalities in memory dysfunctions. In an fMRI study, we investigated grid cell-like representations in the entorhinal cortex of young participants at genetic risk of Alzheimer’s disease as compared to control participants. In the risk carriers, we observed strongly impaired grid cell-like representations, compensatory hyperactivity in the hippocampus, and altered navigational strategies. Together, these studies shed light on the neural basis of intact and impaired content-specific representations in the human brain. 

报告人简介: 

  Prof. Dr. Nikolai Axmacher, Department of Neuropsychology, Institute for Cognitive Neuroscience, Ruhr University Bochum, German 

Academic Positions 

  Since 2014 W3‐Professor for Neuropsychology at the Ruhr University Bochum 

  2014 Chair, Department of Psychology, University of Birmingham (declined) 

  2014 Research group leader, German Center for Neurodegenerative Diseases (DZNE), Bonn (permanent position; declined) 

  2011 – 2014 Emmy Noether group Leader, Department of Epileptology, University of Bonn 

  2011 – 2014 Junior Research group Leader (tenure track), German Center for Neurodegenerative Diseases (DZNE), Bonn 

Editorial board 

  Since 2014 Associate Editor: Cognitive Neuroscience 

  2013 Special Topic Guest Editor: Frontiers in Human Neuroscience 

  Since 2011 Associate Editor: Frontiers in Psychoanalysis and Neuropsychoanalysis 

Research Interests  

  How are experiences represented in the brain and transformed into memory traces? How do these experiences shape our personality? And how is memory compromised by trauma, innerpsychic conflicts and Alzheimer’s dementia? In my group, we are investigating the neural foundations of memory functions and dysfunctions using cognitive neuroscience methods (EEG, fMRI, simultaneous EEG/fMRI, fMRI at 7T, intracranial EEG). I am particularly interested in the processing of specific contents by the brain and how the resulting stimulus specific representations can be decoded using pattern classification algorithms. We are investigating a wide range of memory processes (working memory, long-term memory, memory consolidation during resting state and sleep, autobiographical memory, social memory, repression). 

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